Substance P analogs containing homoglutamine at position of 5 and 6.

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概要

• 論文の詳細を見る

• Six substance P (SP) analogs, in which the glutaminyl residue(s) at the position(s) 5 or/and 6 were replaced by homoglutamine (Hgn), were prepared using a novel N<SUP>α</SUP>,N<SUP>ca</SUP>–(Boc)<SUB>2</SUB>–Hgn–OH by the solid phase method. The activity of the analogs was assayed on isolated guinea pig organs. Results indicate that the elongation of the methylene on glutaminyl residue(s) in SP enhances the activity on isolated guinea pig ileum.

• 公益社団法人 日本化学会の論文

著者

• HASHIMOTO TADASHI

  School of Pharmacy, Hokuriku University

• Uchida Yoshiki

  School Of Pharmacy Hokuriku University

• Sakura Naoki

  School of Pharmacy, Hokuriku University

• Nishijima Miwako

  School of Pharmacy, Hokuriku University

• Moro Tadashi

  School of Pharmacy, Hokuriku University

• Hirose Kyoko

  School of Pharmacy, Hokuriku University

• Kontani Hitoshi

  School of Pharmacy, Hokuriku University

関連論文

• Synthesis of Neurokinin B Analogs and Their Activities as Agonists and Antagonists(Organic,Chemical)
• Syntheses and biological activities of neurokinin A analogs substituted with glycine.
• Tachykinin antagonist. I: Specific, competitive and tissue-selective neurokinin B antagonists on contractile activity in smooth muscles.
• Synthesis and biological activities of D-homoglutamine analogs of substance P.
• Substance P analogs containing homoglutamine at position of 5 and 6.
• Neurokinin B analogs substituted with glycine.
• Syntheses and biological activities of neurokinin B analogs modified at positions 2, 3, and 6.
• Synthesis and biological activity of substance P analogs containing pyrohomoglutamic acid and homoglutamine.

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