Tachykinin antagonist. I: Specific, competitive and tissue-selective neurokinin B antagonists on contractile activity in smooth muscles.

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概要

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• Two neurokinin B (NKB) analogs, [Gly<SUP>6</SUP>]-NKB [3-10] and [Arg<SUP>3</SUP>, DAla<SUP>6</SUP>]-NKB [3-10], were tested for agonistic activity as well as for their ability to antagonize the myotropic actions of NKB, neurokinin A, substance P, physalaemin and eledoisin in isolated guinea-pig ileum, guinea-pig urinary bladder, rat duodenum, rat vas deferens and rat portal vein. [Gly<SUP>6</SUP>]-NKB [3-10] in the guinea-pig ileum and rat portal vein and [Arg<SUP>3</SUP>, D-Ala<SUP>6</SUP>]-NKB [3-10] in the guinea-pig ileum were found to be the first specific and competitive antagonists against NKB.

著者

• HASHIMOTO TADASHI

  School of Pharmacy, Hokuriku University

• Uchida Yoshiki

  School Of Pharmacy Hokuriku University

• SAKAI Takeshi

  School of Pharmacy, Hokuriku University

• NAMINOHIRA Shigeru

  School of Pharmacy, Hokuriku University

関連論文

• Synthesis of Neurokinin B Analogs and Their Activities as Agonists and Antagonists(Organic,Chemical)
• Syntheses and biological activities of neurokinin A analogs substituted with glycine.
• Tachykinin antagonist. I: Specific, competitive and tissue-selective neurokinin B antagonists on contractile activity in smooth muscles.
• Synthesis and biological activities of D-homoglutamine analogs of substance P.
• Substance P analogs containing homoglutamine at position of 5 and 6.
• Neurokinin B analogs substituted with glycine.
• Syntheses and biological activities of neurokinin B analogs modified at positions 2, 3, and 6.
• Synthesis and biological activity of substance P analogs containing pyrohomoglutamic acid and homoglutamine.

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