Syntheses and biological activities of neurokinin A analogs substituted with glycine.

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概要

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• Five neurokinin A (NKA) analogs substituted with glycine at position 3, 4, 5, 6, or 7 were synthesized by Merrifield's solid phase method. The contractile activities of the synthetic analogs were assayed on isolated guinea pig ileum and rat vas deferens. The results suggest that Asp<SUP>4</SUP>, Phe<SUP>6</SUP>, and Val<SUP>7</SUP> residues of NKA may be essential for the intrinsic activity on guinea pig ileum and on rat vas deferens, respectively.

著者

• Kurosawa Katsuro

  School Of Pharmacy Hokuriku University

• HASHIMOTO TADASHI

  School of Pharmacy, Hokuriku University

• Uchida Yoshiki

  School Of Pharmacy Hokuriku University

• Kurosawa Katsuro

  School of Pharmacy, Hokuriku University

関連論文

• Synthesis of Neurokinin B Analogs and Their Activities as Agonists and Antagonists(Organic,Chemical)
• Syntheses and biological activities of neurokinin A analogs substituted with glycine.
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• Neurokinin B analogs substituted with glycine.
• Syntheses and biological activities of neurokinin B analogs modified at positions 2, 3, and 6.
• Synthesis and biological activity of substance P analogs containing pyrohomoglutamic acid and homoglutamine.

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