Synthesis and biological activity of substance P analogs containing pyrohomoglutamic acid and homoglutamine.

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概要

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• Eight substance P analogs substituted by L- or D-pyrohomoglutamic acid (6-oxo-2-piperidinecarboxylic acid) and L or D-homoglutamine at the position 5 and 6 were prepared by the solid phase method. The contractile activities of the analogs were compared with that of SP on isolated guinea-pig organs.

• 公益社団法人 日本化学会の論文

著者

• HASHIMOTO TADASHI

  School of Pharmacy, Hokuriku University

• Uchida Yoshiki

  School Of Pharmacy Hokuriku University

• Sakura Naoki

  School of Pharmacy, Hokuriku University

• Nishijima Miwako

  School of Pharmacy, Hokuriku University

• Moro Tadashi

  School of Pharmacy, Hokuriku University

• Hirose Kyoko

  School of Pharmacy, Hokuriku University

関連論文

• Synthesis of Neurokinin B Analogs and Their Activities as Agonists and Antagonists(Organic,Chemical)
• Syntheses and biological activities of neurokinin A analogs substituted with glycine.
• Tachykinin antagonist. I: Specific, competitive and tissue-selective neurokinin B antagonists on contractile activity in smooth muscles.
• Synthesis and biological activities of D-homoglutamine analogs of substance P.
• Substance P analogs containing homoglutamine at position of 5 and 6.
• Neurokinin B analogs substituted with glycine.
• Syntheses and biological activities of neurokinin B analogs modified at positions 2, 3, and 6.
• Synthesis and biological activity of substance P analogs containing pyrohomoglutamic acid and homoglutamine.

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