Syntheses and biological activities of neurokinin B analogs modified at positions 2, 3, and 6.

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概要

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• Nine neurokinin B [NKB] related octa- and nona-peptides containing Arg and <I>N</I>-methylglycine, D-Ala, D-Phe, D-Trp, D-α-aminophenylacetic acid, D-Arg, D-Pro, D-homoglutamine, or D-homoglutamic acid instead of Met<SUP>2</SUP> or His<SUP>3</SUP>, and Phe<SUP>6</SUP>, respectively, in the original sequences were synthesized by standard solid phase method. The biological activities of the analogs were assayed on isolated guinea-pig ileum. [Arg<SUP>3</SUP>, D-Ala<SUP>6</SUP>]–NKB (3–10) was found to act as an antagonist of NKB.

• 公益社団法人 日本化学会の論文

著者

• Kurosawa Katsuro

  School Of Pharmacy Hokuriku University

• HASHIMOTO TADASHI

  School of Pharmacy, Hokuriku University

• Uchida Yoshiki

  School Of Pharmacy Hokuriku University

• Sakura Naoki

  School of Pharmacy, Hokuriku University

• Hirose Kyoko

  School of Pharmacy, Hokuriku University

• Okimura Keiko

  School of Pharmacy, Hokuriku University

関連論文

• Synthesis of Neurokinin B Analogs and Their Activities as Agonists and Antagonists(Organic,Chemical)
• Syntheses and biological activities of neurokinin A analogs substituted with glycine.
• Tachykinin antagonist. I: Specific, competitive and tissue-selective neurokinin B antagonists on contractile activity in smooth muscles.
• Synthesis and biological activities of D-homoglutamine analogs of substance P.
• Substance P analogs containing homoglutamine at position of 5 and 6.
• Neurokinin B analogs substituted with glycine.
• Syntheses and biological activities of neurokinin B analogs modified at positions 2, 3, and 6.
• Synthesis and biological activity of substance P analogs containing pyrohomoglutamic acid and homoglutamine.

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