A facile, practical synthesis of 2-(6-methoxy-2-naphthyl)propenoic acid.
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概要
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A facile and practical method for the synthesis of 2-(6-methoxy-2-naphthyl)propenoic acid, a precursor of anti-inflammatory agent naproxen, is described. The method involves (1) Pd-catalyzed ethynylation of 2-bromo-6-methoxynaphthalene, (2) regioselective addition of HX to the triple bond, and (3) Pd-catalyzed carbonylation of the resulting vinyl halide followed by (4) alkaline hydrolysis.
- 公益社団法人 日本化学会の論文
著者
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KUSUMOTO Tetsuo
Sagami Chemical Research Center
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Hiyama Tamejiro
Sagami Chemical Research Center
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Ueda Tomoko
Sagami Chemical Research Center
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Wakasa Noriko
Sagami Chemical Research Center
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