Facile conversion of aldehydes into 1-substituted 2-chloro-3,3-difluoro-2-propen-1-ols with 1,1-dibromo-1-chloro-2,2,2-trifluoroethane/magnesium reagent.
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概要
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Aldehydes RCHO are converted in excellent yields into chlorodifluoroallyl alcohols RCH(OH)CCl=CF<SUB>2</SUB> upon treatment with CClBr<SUB>2</SUB>CF<SUB>3</SUB> and magnesium in tetrahydrofuran at 0 °C.
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