Acylation of <I>N</I><SUP>δ</SUP>-Benzyloxyornithine
スポンサーリンク
概要
- 論文の詳細を見る
Acetylation of <I>N</I><SUP>δ</SUP>-benzyloxyornithine monohydrobromide (I·HBr) with acetic anhydride gave the <I>N</I><SUP>δ</SUP>-acetylated product, which yielded <I>N</I><SUP>δ</SUP>-acetyl-<I>N</I><SUP>δ</SUP>-hydroxyornithine by catalytic reduction. On the other hand, acetylation or alkoxycarbonylation of <I>N</I><SUP>δ</SUP>-benzyloxyornithine(I) proceeded through <I>N</I><SUP>α</SUP>-acetylation, followed by spontaneous cyclization to form lactams, which yielded cyclic hydroxamic acids on catalytic reduction. These hydroxamic acid and <I>N</I><SUP>δ</SUP>-acetyl-<I>N</I><SUP>δ</SUP>-hydroxyornithine were readily hydrolyzed to give <I>N</I><SUP>δ</SUP>-hydroxyornithine.
- 公益社団法人 日本化学会の論文
著者
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OHMORI Muneki
Sagami Chemical Research Center
-
Isowa Yoshikazu
Sagami Chemical Research Center
-
Kurita Hideaki
Sagami Chemical Research Center
-
Sato Masanari
Sagami Chemical Research Center
-
Mori Kaoru
Sagami Chemical Research Center
-
Takashima Toshiyuki
Sagami Chemical Research Center
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