The synthesis of peptides by means of proteolytic enzymes.

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概要

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• Nagarse, papain, pepsin and thermolysin were found to catalyze the peptide bond formation between two amino acids or peptides, one protected with a suitable group at the amino group and the other at the carboxyl group. Experiments with various combinations of amino acids and dipeptides show specificity in the catalytic action in varying degree which depending on the nature of the enzyme. Since the condensation takes place efficiently under mild conditions, this method opens up a useful way for the synthesis of peptides.

• 公益社団法人 日本化学会の論文

著者

• OHMORI Muneki

  Sagami Chemical Research Center

• Isowa Yoshikazu

  Sagami Chemical Research Center

• Kurita Hideaki

  Sagami Chemical Research Center

• Ichikawa Tetsuya

  Sagami Chemical Research Center

• Sato Masanari

  Sagami Chemical Research Center

• Mori Kaoru

  Sagami Chemical Research Center

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