Synthesis of an Isoglutathione Derivative by Proteases and Its α→γ Transpeptidation

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概要

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• Benzyloxycarbonyl-L-cysteine and glycine benzhydrylamide were condensed by papain in a yield of 39.5%. After elimination of the N-protecting group, L-cysteinylglycine benzhydrylamide was condensed with benzyloxycarbonyl-L-glutamic acid by acid protease from Irpex lacteus Fr. in a yield of 21.0%. From the isoglutathione derivative thus obtained, αγ-linkage between glutamic acid and cysteine was formed by α→γ transpeptidation in alkaline conditions after esterification of γ-carboxylic acid.

• 社団法人 日本農芸化学会の論文

著者

• Misawa Masanaru

  Tokyo Research Laboratory Kyowa Hakko Kogyo Co. Ltd.

• Isowa Yoshikazu

  Sagami Chemical Research Center

• MISAWA Masanaru

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co.

• HAYASHI Mineyuki

  Tokyo Research Laboratory, Kyowa Hakko Kogyo Co.

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