Improved Solid-Phase Synthesis of Tryptophan-Containing Peptides. II. Use of <I>N</I><SUP>α</SUP>-<I>t</I>-Butyloxycarbonyl-<I>N<SUP>i</SUP></I>-formyltryptophan
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概要
- 論文の詳細を見る
<I>N<SUP>i</SUP></I>-Formyltryptophan has proved to be more resistant than tryptophan against oxidation mediated by hydrogen chloride in acetic acid. <I>N</I><SUP>α</SUP>-<I>t</I>-Butyloxycarbonyl-<I>N<SUP>i</SUP></I>-formyltryptophan has been synthesized <I>via</I> nonaqueous <I>acylation</I> reaction and used for the solid-phase synthesis of tryptophan-containing peptides, in combination with hydrogen chloride in formic acid as the reagent for cleavage of the <I>t</I>-butyloxycarbonyl group. The validity of the method has been demonstrated, on the basis of several criteria, in the synthesis of the tryptophan-containing octapeptide, Lys–Gly–Val–Leu–Ala–Gly–Trp–Leu.
- 公益社団法人 日本化学会の論文
著者
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Izumiya Nobuo
Department Of Industrial Chemistry Faculty Of Engineering Kyushu Sangyo University
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Ohno Motonori
Department Of Applied Life Science Faculty Of Bioscience And Biotechnology Sojo University
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Sato Shin-ichi
Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology
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Tsukamoto Sadaji
Department of Chemistry, Faculty of Science, Kyushu University
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