Improved Solid-Phase Synthesis of Tryptophan-Containing Peptides. I. Use of Hydrogen Chloride in Formic Acid as a Reagent for the Cleavage of <I>t</I>-Butyloxycarbonyl Group

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概要

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• An improved method has been described for the solid-phase synthesis of tryptophan-containing peptides. Hydrogen chloride in formic acid has been introduced as a reagent for the cleavage of the <I>t</I>-butyloxycarbonyl group owing to the stableness of tryptophan and <I>N<SUP>i</SUP></I>-formyltryptophan in this system. The effectiveness of the new reagent has been demonstrated in the synthesis of the tryptophan-containing heptapeptide, lysylalanylglycyl-leucylglycyltryptophylleucine.

• 公益社団法人 日本化学会の論文

著者

• Ohno Motonori

  Department of Chemistry, Faculty of Science, Kyushu University

• Tsukamoto Sadaji

  Department of Chemistry, Faculty of Science, Kyushu University

関連論文

• Crystal Structure Analysis of Phospholipase A_2 from Trimeresurus flavoviridis (Habu Snake) Venom at 1.5 A Resolution
• Improved Solid-Phase Synthesis of Tryptophan-Containing Peptides. II. Use of Nα-t-Butyloxycarbonyl-Ni-formyltryptophan
• Improved Solid-Phase Synthesis of Tryptophan-Containing Peptides. I. Use of Hydrogen Chloride in Formic Acid as a Reagent for the Cleavage of t-Butyloxycarbonyl Group

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