Substituent effects on 6-substituted 3-hydroxy-1-methyl-4-pyridones.
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概要
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Acid dissociation constants and UV and NMR spectra of a series of 6-substituted 3-hydroxy-1-methyl-4-pyridones have been measured. The acid dissociation constants have been analyzed in terms of the Hammett equation to give linear relationships, with ρ=1.16 for the conjugate acids and ρ=1.06 for the neutral compounds. Halochromism in the UV spectra gave the equation: Δ\tildeν=689 p<I>K</I><SUB>a</SUB>−9399, and the Hammett plots of the chemical shifts of the 2-H, 5-H, and CH<SUB>3</SUB> protons gave linear relationships, with ρ=1.78, 2.56, and 1.39, respectively.
- 公益社団法人 日本化学会の論文
著者
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IMAFUKU Kimiaki
Department of Chemistry, Faculty of Science, Kumamoto University
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Matsumura Hisashi
Department of Chemistry, Faculty of Science, Kumamoto University
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Takahashi Kumio
Department of Chemistry, Faculty of Science, Kumamoto University
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