X-Ray Diffraction Studies of the Molecular Complexes of Tetracycline Salts

概要

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An examination of the salt-complexes of tetracycline and oxytetracycline by the X-ray powder method has shown the presence of at least four different kinds of crystal structures, i.e., the dα, dβ, hγ, and hδ forms. Among them, the dα form has been studied in detail by the use of single crystals. The monoclinic unit cell dimensions of the dα crystals do not vary much either with a salt anion or with a complexing agent, and the intensities of the various reflections so far examined are very similar. On the basis of these findings, it is suggested that the crystal structures of the dα-type salt-complexes consist of an almost identical framework of tetracycline or oxytetracycline molecules which encloses spaces capable of containing complexing agents of various types. The orthorhombic dβ form is a polymorphic modification of the dα form, probably arising from submicroscopically polysynthetic twinning of the latter.
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