特定集団における抗甲状腺抗体と血清TSH
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概要
- 論文の詳細を見る
Circulating thyroid antibodies are important markers for detecting autoimmune thyroid diseases. A survey was conducted in Daiwa Village, Shimane Prefecture, to determine the incidence of significant asymptomatic autoimmune thyroiditis, in a rural population. One thousand two hundred and forty-two people were examined in the survey. The incidence of overt thyroid disorders was 3/570 males and 12/672 females. Eight were cases of hyperthyroidism and three were diffuse or nodular goiter. Three were postoperative cases of struma, including thyroid cancer, and the other one was that of overt hypothyroidism. We examined antithyroglobulin antibodies (TG) and thyroid microsomal antibodies (MS), excluding 15 patients with overt thyroid diseases. TG and MS were measured by the tanned red cell hemagglutination technique, using commercially available kits, Thyroid Test and Microsome Test (Fuzi Zoki, Tokyo). Eight of 567 (1.4%) males were positive for TG and 32 (5.6%) were positive for MS. Twenty-five of 660 (3.8%) females were positive for TG and 73 (11.1%) were positive for MS. The incidence of TG and/or MS was higher in females. Age-specific prevalence of antithyroid antibodies gradually increased in those over 40. We examined the serum cholesterol levels in subjects with thyroid autoantibodies and also in controls and we found no statistical significance. The serum TSH levels were also studied. 3.9pU/ml, which was the mean serum TSH level in subjects with thyroid autoantibodies, was significantly higher than 2.3μU/ml, such being the mean serum TSH level in controls matched according to sex and age (p<0.01). There was a correlation between the serum TSH levels and the titers of thyroid microsomal antibodies.<BR>Four had high levels in the serum thyrotropin (>10/μU/ml), that is 20.1, 18.0, 15.7 and 10.8μU/ml. All were positive for MS and the only one of four was positive for TG. These patients were re-examined for clinical signs of thyroid disorders. We palpated a small goiter in one and tentative diagnosis of Hashimoto's thyroiditis was made. The other three seemed to be cases of significant asymptomatic autoimmune thyroiditis. We consider that detection of MS may be more pertinent than that of TG.
- 日本内分泌学会の論文
著者
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国司 博行
島根医科大学附属病院 輸血部
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遠藤 治郎
島根医科大学
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野津 吉友
島根医科大学附属病院 検査部
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野津 和巳
島根医科大学
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桜美 武彦
島根医科大学内科第一講座
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後藤 康生
島根医科大学
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後藤 康生
島根医科大学 第一内科
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野手 信哉
島根医科大学 第一内科
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平田 正名
島根医科大学 第一内科
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桜美 武彦
島根医科大学 第一内科
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野津 吉友
島根医科大学 中央検査部
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国司 博行
島根医科大学 中央検査部
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