成長因子としてのトランスフェリン測定の臨床的意義:第一報 : 下垂体疾患治療前後での変化

概要

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The concentrations of plasma transferrin (Tf), which has been described as possessing growth promoting activity in vitro, were determined in patients with various endocrine diseases before and after treatment. Plasma Tf levels in 74 healthy subjects were 269 ± 3 (mean ± SE) mg/dl. In 11 patients with active acromegaly, they were elevated to 353 ± 11 mg/dl (p<0.001), while they were reduced to 168 ± 14 mg/dl in 8 patients with hypopituitarism (p<0.001). They were normalized after treatment. These data indicate that plasma Tf varies according to the endocrine conditions with good correlation of the status of plasma somatomedin C, and therefore its measurement may be useful clinically for the evaluation of the status of growth factors. However, the values should be assessed carefully in cases with proper Tf abnormalities, such as hematological, hepatic, or renal disorders.