再発消化器癌に対するLow dose CDDP/5-FU併用化学療法

概要

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We conducted a pilot study to evaluate a continuous 24-hour infusion of 5-fluorouracil (5-FU) 300-500mg /body/day plus low-dose cisplatin (CDDP) 5-10mg/body/day by bolis infusion on day's 1-5 in patients with recurrent digestive cancer.<BR>A total of 22 pa tients with recurrent digestive cancer (5 cases of esophgeal cancer,14 cases of gastric cancer,2case of colon cancer and 1 case of pancreatic cancer) were enrolled in this study. This regimen was repeated weekly for four to six courses according to response and tolerance. The overall response rate were 40.9% (8 PRs and 1 CR). Side effects were generally mild and tolerable, including leukopenia and thrombocytopenia (WHO grade 3or4) ocurred in 1/22 (4.5%) and 1/22 (4.5%) patients, respectively. Renal toxicities were not observed.<BR>Bades on the results of this study, combination chemotherapy with continuous low-dose cisplatin is considered to be safe and effective against recurrent digestive cancer.