糖代謝とアミノ酸代謝との関連:ホルモンによる代謝調整を中心として
スポンサーリンク
概要
- 論文の詳細を見る
The changes of the activities of serine dehydratase (SDH) and glucokinase were examined in order to evaluate dietary and hormonal effects on the metabolism of amino acids and carbohydrate.<BR>1) In the livers of alloxan-diabetic rats, about a sixfold increase of SDH was observed, and this increase was diminished to the normal level by the injection of protamine zinc insulin. The increase was inhibited approximately 75% by an administration of actinomycin S. Adrenalectomized rats showed no increase of SDH for 48 hours after the injection of alloxan monohydrate, although a gradual increase was observed 3 to 4 days later.<BR>On the basis of these facts, adrenalectomized rats treated with alloxan monohydrate at zero time, were given three injections of 5 mg of hydrocortisone acetate at 15, 24 and 40 hours and then sacrificed at 45 hours. SDH was enhanced about fivefold, whereas no increase was found without the alloxan treatment. In normal rats, daily administration of 15mg of hydrocortisone acetate for 3 days produced only a 1.7 fold increase. No increase of SDH was observed in rats which were hypophysectomized either before or after the injection of alloxan monohydrate. An injection of somatotrophic hormone proved to be ineffective on SDH in the hypophysectomized alloxan-diabetic rats.<BR>2) The activity of glucokinase decreased to one seventh of normal level in the liver of alloxan-diabetic rats. The activity returned to normal level by the injection of protamine zinc insulin. Adrenalectomy showed no inhibitory effect on the decrease of glucokinase in the alloxan-diabetic rats. Hydrocortisone acetate could not affect the activity of glucokinase in the liver of adrenalectomized alloxan-diabetic rats.<BR>3) No increase of SDH was observed after starvation for 3 days. In the rats fed with high protein diet, SDH increased to the same level as in the alloxan-diabetic rats.<BR>4) As indicated by the activity of SDH, the conversion of serine to pyruvate increases in the liver of alloxan-diabetic rats, and pyruvate is synthesized to glucose through the pathway of the activated gluconeogenesis. The utilization of glucose is inhibited in the diabetic rats as shown by the decreased activity of glucokinase.<BR>5) The response of SDH to hydrocortisone as evidenced by the elevation of SDH activity in adrenalectomized alloxan-diabetic rats supports the view that insulin counteracts the effect of hydrocortisone on SDH. Of special interest in this connection, there are similar reciprocal changes between the activites of SDH and glucokinase in the livers of alloxan-diabetic and high protein-fed rats compared with normal rats.<BR>It is a problem to be solved whether a dietary stress might regulate the flow rate of metabolites via hormonal control.
- 日本内分泌学会の論文
著者
関連論文
- 胎盤潅流実験による胎盤内分泌機能の解明 (胎盤の内分泌 : 胎盤を接点とした母児内分泌機能について)
- 3. 子宮体部癌の estradiol 依存性, 特に estradiol binding sites 測定による approach について
- 85. 不妊検査における LH-RH テストの意義
- 胎児管理法としての血中エストリオール抱合形測定の意義
- 129. 妊婦におけるエストリオール抱合形の産生代謝に関する研究
- 45. 子宮内膜におけるプロスタグランディン産生と,その生理的意義について
- 子宮内膜癌のホルモン依存性に関する研究
- 236. 赤血球凝集阻止反応によるPGF_2α MUMの簡易測定法の開発とその分娩管理への応用について
- 232. ヒト性周期における子宮内膜中Prostaglandinsの局在の変動と月経発来機構について
- 177. anti hCG-β sansitized erythrocytesを利用したrapid radioimmunoassay (第13群 診断・検査 (177〜193))
- 3. 子宮内膜癌のホルモン依存性の本態解明に関する研究 (第1群 悪性腫瘍 (1〜27))
- UrokinaseとUrokinase Inhibitorの生物学的結合能を利用した尿中Urokinase Inhibitorの免疫学的測定法の開発とその臨床応用
- 月経困難症患者における月経血中プロスタグラノディン濃度について
- 51. 腎臓におけるsteroid代謝
- 108. Pregnane系 steroidの代謝及び生合成について : 第2報 progesterone生合成機構の解明について
- 子宮筋におけるProstaglandinレセプターの変動に関する研究 : prostaglandinとsteroidの相互作用を中心として
- 2.血中pregnenolone sulfateの微量測定 : 妊婦血中progesterone濃度との関連について(第1群ホルモンI)
- 4.血中Progesteroneの測定に関する研究 : 〔Electrone Capture Detectro付Gas Liquid Chromatography(ECD付GLC)及びCompetitive Protein Binding Method(CPB法)による〕(第1群ホルモンI)
- プロスタグランディンF_尿中主要代謝産物濃度と分娩日との関係について
- 月経発来機序に関する研究
- 糖代謝とアミノ酸代謝との関連:ホルモンによる代謝調整を中心として