DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology
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概要
- 論文の詳細を見る
Aberrant DNA methylation is associated with cancer development and progression. There are several types of specimens from which DNA methylation pattern can be measured and evaluated as an indicator of disease status (from normal biological process to pathologic condition) and even of pharmacologic response to therapy. Blood-based specimens such as cell-free circulating nucleic acid and DNA extracted from leukocytes in peripheral blood may be a potential source of noninvasive cancer biomarkers. In this article, we describe the characteristics of blood-based DNA methylation from different biological sources, detection methods, and the factors affecting DNA methylation. We provide a comprehensive literature review of blood-based DNA methylation as a cancer biomarker and focus on the study of DNA methylation using peripheral blood leukocytes. Although DNA methylation patterns measured in peripheral blood have great potential to be useful and informative biomarkers of cancer risk and prognosis, large systematic and unbiased prospective studies that consider biological plausibility and data analysis issues will be needed in order to develop a clinically feasible blood-based assay.
著者
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Park Sue
Department Of Preventive Medicine Seoul National University College Of Medicine
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Li Lian
Department Of Biology Pennsylvania State University
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Yuasa Yasuhito
Department Of Hygiene And Oncology Tokyo Medical And Dental University School Of Medicine
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Fang Jing-yuan
Shanghai Institute Of Digestive Disease Shanghai Second Medical University
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Kim Woo
Department Of Biology College Of Science Yonsei University
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Oze Isao
Division Of Epidemiology And Prevention Aichi Cancer Center Research Institute
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Matsuo Keitaro
Division of Cardiology, Nippon Medical School
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CHEN Ying-Xuan
Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao-Tong University School of Medicine
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CHOI Ji-Yeob
Department of Biomedical Sciences, Graduate School of Seoul National University
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SUNG Hyuna
Department of Biomedical Sciences, Graduate School of Seoul National University
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LEE Kyoung-Mu
Department of Environmental Health, Korea National Open University
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PAN Kai-Feng
Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
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YOU Wei-Cheng
Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
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PAN Kai-Feng
Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
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FANG Jing-Yuan
Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiao-Tong University School of Medicine
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YUASA Yasuhito
Department of Molecular Oncology, Tokyo Medical and Dental University
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KANG Daehee
Department of Biomedical Sciences, Seoul National University College of Medicine
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LI Lian
Department of Preventive Medicine, Seoul National University College of Medicine
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YOU Wei-Cheng
Department of Cancer Epidemiology, Peking University School of Oncology, Beijing Cancer Hospital & Institute
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