Change in pulmonary and systemic circulation in acute ventricular septal defect.
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概要
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The correlation between left to right ventricular (L-R) shunt flow and other hemodynamic changes was studied in 16 dogs with an acute ventricular septal defect (VSD) and normal pulmonary vascular bed. The interventricular shunt flow was measured directly with a specially designed electromagnetic flowmeter probe, where the area of the VSD was constant.The sudden presentation of VSD increased pulmonary arterial pressure, pulmonary flow and left ventricular end-diastolic pressure.L-R shunt flow was not changed significantly by atrial pacing except when the rate was increased to over 200/min.Dogs with a VSD were treated with isoproterenol and dextran to vary the shunt flow and hemodynamic parameters. L-R shunt flow was decreased by isoproterenol and increased by dextran loading.The percentage changes of L-R shunt flow from pre-drug values correlated well with the change in left ventricular enddiastolic pressure (r=0.75) and the ratio of pulmonary to systemic vascular resistance (r=-0.73). Change in total pulmonary vascular resistance had a greater effect on L-R shunt flow than did a change in systemic vascular resistance, whereas a change in aortic flow had less effect (r=0.35) on L-R shunt flow than did a change in preload and afterload. The time to peak LV dP/dt, as an index of cardiac contractility, and heart rate were not correlated with the relative change in L-R shunt flow.These results indicate that L-R shunt flow induced by the sudden presentation of a VSD varied with changes in the pulmonary and systemic circulation.
- International Heart Journal刊行会の論文
著者
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MATSUOKA SUGURU
Department of Pediatrics
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Tomimatsu Hirofumi
Department Of Pediatric Cardiology Tokyo Women's Medical University
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Nakatsu Tadanori
Department Of Pediatrics School Of Medicine Tokushima University
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Yuasa Yasuhito
Department Of Hygiene And Oncology Tokyo Medical And Dental University School Of Medicine
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Miyao Masuhide
Department Of Pediatrics School Of Medicine Tokushima University
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Miyauchi Yoshio
Department Of Pediatrics School Of Medicine Tokushima University
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Tomimatsu Hirofumi
Department of Pediatrics, School of Medicine, Tokushima University
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YUASA Yasuhito
Department of Pediatrics, School of Medicine, Tokushima University
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