Beta-Blocker Therapy for Cardiac Dysfunction in Patients With Muscular Dystrophy
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概要
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Background In muscular dystrophy, cardiac function deteriorates with time and heart failure is one of the major causes of death. Although the combination of angiotensin-converting enzyme inhibitors (ACEI) and β-blockers improves cardiac function in adults, little is known about the efficacy of those drugs in patients with muscular dystrophy. Methods and Results The effect of the β-blocker, carvedilol, and/or ACEI on ventricular function in patients with muscular dystrophy was studied. Carvedilol and an ACEI were given to 13 patients (ACEI group; mean age 18 years, range 7-27 years), and an ACEI only to 15 patients (carvedilol group; mean age 15 years, range 8-29 years). Diagnoses included Duchenne muscular dystrophy (n=25), Fukuyama muscular dystrophy (n=2), and Emery-Dreifuss muscular dystrophy (n=1). Echocardiographic parameters of the left ventricle were measured during the 2-3 years of follow-up. In the carvedilol group, combination therapy of carvedilol and an ACEI for 2 years resulted in a significant increase in left ventricular fractional shortening (LVFS). In the ACEI group, there was no significant change in LVFS. Left ventricular end-diastolic dimension increased in the ACEI group, but not in the carvedilol group. Conclusion Carvedilol plus an ACEI improves left ventricular systolic function in patients with muscular dystrophy.
- 社団法人日本循環器学会の論文
- 2006-07-20
著者
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Nakazawa Makoto
Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Womens Medical University
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KAJIMOTO Hidemi
Department of Internal Medicine, Division of Cardio-Vascular Medicine, Kurume University School of M
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Tomimatsu Hirofumi
Department of Pediatric Cardiology, Tokyo Women's Medical University
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Nakanishi Toshio
Department Of Pediatric Cardiology Heart Institute Tokyo Women's Medical University
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Osawa Makiko
Department of Pediatrics, Tokyo Women's Medical University
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ISHIGAKI Keiko
Department of Pediatrics, Tokyo Women's Medical University
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SAITO Kayoko
Department of Pediatrics, Tokyo Women's Medical University
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Oosawa Makiko
Department Of Pediatrics Tokyo Women's Medical University
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Tomimatsu Hirofumi
Department Of Pediatric Cardiology Tokyo Women's Medical University
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Kajimoto Hidemi
Department Of Internal Medicine Division Of Cardio-vascular Medicine Kurume University School Of Med
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Kajimoto Hidemi
Department Of Pediatric Cardiology Heart Institute Of Japan Tokyo Women's Medical University
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Ishigaki Keiko
Department Of Pediatrics Tokyo Women's Medical University
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Ishigaki Keiko
Department Of Anesthesiology Faculty Of Medicine University Of The Ryukyus
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Okumura Kenichi
Department of Pediatric Cardiology, Tokyo Women's Medical University
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Okumura Kenichi
Department Of Pediatric Cardiology Tokyo Women's Medical University
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Saito Kayoko
Tokyo Women's Medical University School Of Medicine Department Of Pediatrics
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Saito Kayoko
Department Of Pediatrics Tokyo Women's Medical University School Of Medicine
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Saito Kayoko
Department Of Neuropsychiatry School Of Medicine Hirosaki University
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Nakanishi Toshio
Department Of Pediatric Cardiology Heart Institute Of Japan Tokyo Women's Medical University
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Osawa Makiko
Department Of Pediatrics Tokyo Woman's Medical University
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Nakanishi Toshio
Department Of Internal Medicine Kure City Medical Association Hospital
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Nakayama Tomohiro
Department Of Pediatrics Tokyo Women's Medical University
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Osawa Makiko
Department Of Pediatrics Faculty Of Medicine Tokyo Women's Medical University
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Nakazawa Makoto
Department Of Pediatric Cardiology Heart Institute Tokyo Women's Medical University
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Nakanishi Toshio
Department Of Gastroenterology Miyoshi Central Hospital
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Nakazawa Makoto
Department Of Pediatric Cardiology Heart Institute Of Japan Tokyo Women's Medical College
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Nakayama Tomohiro
Department Of Pediatric Cardiology Heart Institute Of Japan Tokyo Women's Medical University
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Nakayama Tomohiro
Department Of Pediatric Cardiology Tokyo Women's Medical University
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Osawa Makiko
Department of Pediatrics, School of Medicine, Tokyo Women's Medical University
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