Aortic Reservoir Function After Arterial Switch Operation in Elementary School-Aged Children
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概要
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Background After the arterial switch procedure, decreased distensibility of the aortic root has been reported, which means impaired aortic reservoir function of the coronary circulation, but there have been no reports regarding the relationship of this issue to myocardial perfusion. Therefore, in the present study the aortic reservoir function and coronary supply-demand balance were examined in patients after undergoing the arterial switch operation (ASO) around the time of entering elementary school. Methods and Results Diastolic runoff (DR), which is the percentage of diastolic blood flow to total cardiac output, was measured as the index of aortic reservoir function. The subendocardial viability ratio was investigated as the index of coronary supply-demand balance. In the patient group, the aortic root was dilated (p<0.0001) and distensibility was impaired (p<0.0001) in comparison with an age-matched control group. However, there was no difference between the 2 groups in DR or subendocardial viability ratio. Conclusions Coronary supply-demand balance was preserved in the pediatric ASO patients, despite the aortic root dysfunction. The preserved DR suggests that dilatation of the aorta compensates for aortic reservoir function. Because large artery dysfunction predicts future cardiovascular diseases, careful follow-up is crucial.
- 社団法人日本循環器学会の論文
- 2008-07-20
著者
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UENO Michihiko
Department of Pediatrics and Developmental Medicine, Hokkaido University, Graduate School of Medicin
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MURAKAMI Tomoaki
Department of Pediatrics and Developmental Medicine, Hokkaido University, Graduate School of Medicin
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TAKEDA Atsuhito
Department of Pediatrics and Developmental Medicine, Hokkaido University, Graduate School of Medicin
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Nakazawa Makoto
Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Womens Medical University
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TAKEI Kohta
Department of Pediatric Cardiology, Nagano Children's Hospital
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Takei Kohta
Department Of Pediatric Cardiology Nagano Children's Hospital
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Takei Kohta
Department Of Pediatrics Hokkaido University Graduate School Of Medicine
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Yakuwa Satoshi
Department Of Pediatrics Hokkaido University Graduate School Of Medicine
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Ueno Michihiko
Department Of Pediatrics Hokkaido University Graduate School Of Medicine
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Nakazawa Makoto
Department Of Pediatric Cardiology Heart Institute Tokyo Women's Medical University
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Murakami Tomoaki
Department Of Ophthalmology And Visual Sciences Kyoto University Graduate School Of Medicine
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Nakazawa Makoto
Department Of Pediatric Cardiology Heart Institute Of Japan Tokyo Women's Medical College
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Nakazawa Makoto
Department Of Pediatric Cardiology Tokyo Women's Medical University School Of Medicine Tokyo An
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Takeda Atsuhito
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women's Medical Universit
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Murakami Tomoaki
Department of Pediatrics, Hokkaido University Graduate School of Medicine
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Ueno Michihiko
Department of Pediatrics, Hokkaido University Graduate School of Medicine
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Takeda Atsuhito
Department of Pediatrics, Hokkaido University Graduate School of Medicine
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Yakuwa Satoshi
Department of Pediatrics, Hokkaido University Graduate School of Medicine
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