ACUTE HEMODYNAMIC EFFECTS OF DOPAMINE, DOBUTAMINE, AND ISOPROTERENOL IN CONGESTED INFANTS OR YOUNG CHILDREN WITH LARGE VENTRICULAR SEPTAL DEFECT
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概要
- 論文の詳細を見る
We studied the acute hemodynamic effects of dopamine, dobutamine, and isoproterenol in infants and young children with large ventricular septal defect (VSD). Dopamine (5 μg/kg/min) had no significant hemodynamic effects. Dobutamine (5 μg/ kg/ min) administration resulted in modest increases in heart rate and systemic arterial pressure and a decrease in left atrial pressure. This drug decreased the pulmonary blood flow, and the pulmonary-to-systemic blood flow (Qp/Qs) ratio, although these changes were not statistically significant. Isoproterenol, infused at doses of 0.03 and 0.06 μg/kg/min, increased the heart rate and lowered left atrial pressure. Only the high dose of isoproterenol lowered systemic and pulmonary arterial pressure. The low dose infusion of this drug increased the pulmonary blood flow as well as the systemic flow, whereas the high dose infusion resulted in a decrease of the Qp/Qs ratio without an increase in the pulmonary blood flow. Right atrial pressure was lowered by dobutamine and the high dose of isoproterenol, but the mean change was only 1 to 2 mmHg. The difference of the effects among these catecholamines is due to their relative strength of action on the vascular bed and the myocardium. Although the doses and durations of the drug infusions were limited, these acute hemodynamic effects should be taken into account when they are to be given to congested infants and young children large VSD.
- 社団法人日本循環器学会の論文
- 1987-09-20
著者
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Takanashi Yoshinori
Departments Of Pediatric Cardiology And Pediatric Cardiovascular Surgery The Heart Institute Of Japa
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Takao Atsuyoshi
Department Of Cardiology Tokyo Women's Medical University
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Nakazawa Makoto
Department of Pediatric Cardiology, Heart Institute of Japan, Tokyo Womens Medical University
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Tokuyasu Yoshiki
Departments Of Pediatric Cardiology And Pediatric Cardiovascular Surgery The Heart Institute Of Japa
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Nakazawa Makoto
東京女子医科大学 循環器小児科
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Takao Atsuyoshi
Cardiology Tokyo Women's Medical University
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Okuda Hirohumi
Departments Of Pediatric Cardiology And Pediatric Cardiovascular Surgery The Heart Institute Of Japa
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Okuda Hirofumi
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women 's Medical College
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Aiba Sumi
Department of Pediatric Cardiology, The Heart Institute, Tokyo Women's Medical College
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TAKAHASHI YSHIAKI
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women 's Medical College
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OHTA FUMIO
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women 's Medical College
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Takao Atsuyoshi
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women 's Medical College
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Nakazawa M
Jasri Spring-8
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Okuda Hirohumi
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women 's Medical College
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Aiba Sumi
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women 's Medical College
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Ohta Fumio
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women 's Medical College
-
Nakazawa Makoto
Department Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women 's Medical College
-
Takao Atsuyoshi
Pediatric Cardiology Heart Institute Tokyo Women's Medical College
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Takanashi Yoshinori
Department Of Cardiovascular & Pediatric Cardiovascular Surgery The Heart Institute Of Japan Tok
-
Takao Atsuyoshi
Department Of Cardiology The Heart Institute Of Japan Tokyo Women's Medical University
-
Takao Atuyoshi
Dept. Of Pediatric Cardiology The Heart Institute Of Japan Tokyo Women's Medical College
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Takao Atsuyoshi
Division Of Pediatrics And Surgery Heart Institute Tokyo Women's Medical College.
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Takahashi Yoshiaki
Department Of Cardiovascular & Pediatric Cardiovascular Surgery The Heart Institute Of Japan Tok
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Nakazawa Makoto
Department Of Pediatric Cardiology Heart Institute Tokyo Women's Medical University
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Nakazawa Makoto
Department Of Pediatric Cardiology Heart Institute Of Japan Tokyo Women's Medical College
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Tokuyasu Yoshinori
Tokyo Women's Medical College The Heart Institute Of Japan
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Okuda Hirofumi
Department of Chemistry, Faculty of Science and Engineering, Saga University
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