Correlation of Plasma Amino Acid Concentrations and Chondroprotective Effects of Glucosamine and Fish Collagen Peptide on the Development of Osteoarthritis

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概要

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• We investigated the correlation of plasma amino acid concentrations as well as the effects of glucosamine and fish collagen peptide (FCP) on osteoarthritis (OA). OA was induced according to the rabbit anterior cruciate ligament transection model. After surgery, the rabbits were orally administered with FCP (F group), glucosamine (G group), or both (FG group) for 4 weeks. The control group (C group) was not administered any. Blood was collected before the surgery (pre-ACLT) and before euthanasia (post-ACLT). Changes in the alanine, threonine, and methionine concentrations were significant between pre- and post-ACLT. The correlation between the histological assessment and arginine concentration at post-ACLT was significant. These findings indicate the measurement of plasma amino acids is useful for evaluation of the efficacy of intervention of OA.

著者

• Imagawa Tomohiro

  Department Of Basic Veterinary Science The United Graduate School Of Veterinary Science Yamaguchi Un

• Tsuka Takeshi

  Department of Veterinary Diagnostic Imaging, Faculty of Agriculture, Tottori University

• Minami Saburo

  Department Of Veterinary Surgery Faculty Of Agriculture Tottori University

• Ohnishi Akihiro

  Department Of Central Laboratory Daisan Hospital Jikei University School Of Medicine

• OSAKI Tomohiro

  Department of Veterinary Surgery, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan

• OKAMOTO Yoshiharu

  Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

• Okamoto Yoshiharu

  Department of Chemistry, Faculty of Science, Hiroshima University

• MATAHIRA Yoshiharu

  R & D Division, Yaizu Suisankagaku Co., Ltd., 5–8–13 Ogawa-Shinmachi, Yaizu, Shizuoka 425–8570, Japan

• MINAMI Saburo

  Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

• MATAHIRA Yoshiharu

  R & D Division, Yaizu Suisankagaku Co., Ltd., 5–8–13 Ogawa-Shinmachi, Yaizu, Shizuoka 425–8570, Japan

• TSUKA Takeshi

  Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

• OSAKI Tomohiro

  Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

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