Photodynamic Hyperthermal Therapy with Indocyanine Green (ICG) induces Apoptosis and Cell Cycle Arrest in B16F10 Murine Melanoma Cells

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概要

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• We examined the effects of photodynamic hyperthemal therapy (PHT), which is a combination of photodynamic therapy (PDT) and hyperthermia (HT), on the apoptosis and cell cycle progression of murine melanoma B16F10 cells. The percentage of apoptotic cell was determined by flow cytometry using fluorescein isothiocyanate (FITC)-conjugated Annexin V and propidium iodide (PI) double staining. The cell cycle analysis was performed by PI staining with flow cytometry. The expression of cyclins and heat shock protein 70 (Hsp70) were examined by a Western blotting analysis. PHT induces death in B16F10 cells, and PHT-mediated apoptosis occurred acutely and persistently in vitro. Our study demonstrated that PHT using indocyanine green (ICG) and near infrared (NIR) light source induces apoptosis and G0/G1 cell cycle arrest in the B16F10 cells.

著者

• Imagawa Tomohiro

  Department Of Basic Veterinary Science The United Graduate School Of Veterinary Science Yamaguchi Un

• Tsuka Takeshi

  Department of Veterinary Diagnostic Imaging, Faculty of Agriculture, Tottori University

• Minami Saburo

  Department Of Veterinary Surgery Faculty Of Agriculture Tottori University

• TSUKA Takeshi

  Department of Veterinary Diagnostic Imaging, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan

• RADZI Rozanaliza

  The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan

• OSAKI Tomohiro

  Department of Veterinary Surgery, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan

• MINAMI Saburo

  Department of Veterinary Surgery, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan

• NAKAYAMA Yuji

  Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University

• Okamoto Yoshiharu

  Department of Chemistry, Faculty of Science, Hiroshima University

• RADZI Rozanaliza

  The United Graduate School of Veterinary Science, Yamaguchi University, Yoshida 1677-1, Yamaguchi 753-8515, Japan

• MINAMI Saburo

  Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

• TSUKA Takeshi

  Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

• OSAKI Tomohiro

  Department of Veterinary Clinical Medicine, Tottori University, 4-101 Koyama-Minami, Tottori 680-8553, Japan

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