Application of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Discrimination of Laboratory-Derived Antibiotic-Resistant Bacteria
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概要
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The ability of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) to discriminate laboratory-derived antibiotic-resistant bacterial strains of known genetic origin was examined. A computer-based cluster analysis of spectral data successfully discriminated the majority of single- as well as multiple-antibiotic-resistant Escherichia coli strains examined. Cluster analysis of Staphylococcus aureus strains with different levels of novobiocin resistance showed that as the degree of resistance increased similarity to the wild-type strain decreased. These results demonstrate that MALDI-TOF MS is capable of discriminating antibiotic-resistant bacterial strains and may have potential for differentiating bacterial strains with varying degrees of antibiotic-resistance.
著者
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IGARASHI MASAYUKI
Microbial Chemistry Research Center
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Shima Keisuke
Analytical & Measuring Instruments Division, Shimadzu Corporation
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Nakagawa Yasuyoshi
Resource Collection Division, National Institute of Technology and Evaluation
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Tanamoto Ken-ichi
Research Institute Of Pharmaceutical Sciences Musashino University
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Muroi Masashi
Research Institute Of Pharmaceutical Sciences Musashino University
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Igarashi Masayuki
Microbial Chemistry Research Foundation
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Shima Keisuke
Analytical & Measuring Instruments Division, Shimadzu Corporation
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