Bioproduction of Cinchona Alkaloids by the Endophytic Fungus Diaporthe sp. Associated with Cinchona ledgeriana

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概要

• 論文の詳細を見る

• We report that an endophytic filamentous fungus species of the genus Diaporthe isolated from Cinchona ledgeriana (Rubiaceae) produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) upon cultivation in a synthetic liquid medium. This study provides evidence that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in the endophytic microbe cells, and will help to elucidate the relationship between endophytic microbes and their host plants.

• 公益社団法人　日本薬学会の論文

著者

• OHASHI Kazuyoshi

  Faculty of Pharmacy and Parmaceutical Sciences, Fukuyama University

• KITAMURA Chinami

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• MAEHARA Shoji

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Shibuya Hirotaka

  Faculty Of Pharmaceutical Sciences Fukuyama University

• Kitamura Chinami

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• Simanjuntak Partomuan

  Research Center For Biotechnology Indonesian Institute Of Sciences

• Simanjuntak Partomuan

  Research Center for Biotechnology, Indonesian Institute of Sciences

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