即時型皮内反応に及ぼす種々の薬剤の影響

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Generally speaking, asthmatic patients were administered various drugs such as xanthines, β-stimulants, antihistamines and drugs which inhibit chemical mediator release from mast cells (ef. sodium cromoglycate and traxanox) . In order to study whether these drugs will effect immediate skin reaction with allergens or not, asthmatic patients received skin tests with house dust. Formoterol 40μg, aminophyllin 20 mg, traxanox 90 mg, clemastine 1 mg were administered orally before skin test. None of them inhibited immediate skin reaction with house dust. Combined use of aminophylline, salbutamol and clemastine also did not inhibit immediate skin reaction with house dust. But, prior treatment with aminophylline 500 mg intravenously inhibited immediate skin reaction at 15-20μg/ml serum theophylline levels.
学校法人昭和大学・昭和医学会の論文