サイクロセリン投与時の担癌個体におけるβ-アミノイソ酪酸の排泄について

概要

論文の詳細を見る
It is known that urninary β-aminoisobutyric acid (BAIBA) excretion levels increase after irradiation. Due to the fact that BAIBA is a catabolite of thymine derived from DNA, it is possible to indirectly determine thymine catabolism by measuring urinary BAIBA levels ; however, BAIBA is metabolized further in low BAIBA excretors, so it is not possible to conclude that BAIAB excretion levels reflect thymine catabolism. In addition, it is thought that low excretors can be managed, as well as high excretors, with antituberculotic cycloserine administration, inhibiting aminotransferase which metabolizes BAIBA. In a study of nuclear acid metabolism, particularly thymine catabolism, tumor bearing rats that were administered cycloserine, were irradiated. Their BAIBA excretion levels increased and excretion peak level was more remarkable than without cycloserine administration.