鶏胎仔Cholinesterase,Monoamine oxidaseの変化とこれにおよぼすOrganophosphateの影響

概要

論文の詳細を見る
The development of cholinesterase (ChE) and monoamine oxidase (MAO) has been studied in the brain, liver and eye ball of chick embryo and chick, using acetylcholine (ACh), acetyl-β-methylcholine (MeCh), butyrylcholine (BuCh), benzoylcholine (BzCh), benzylamine and tyramine as substrates. ChE activities in the brain of chick embryo and chick were observed in high activities when ACh or MeCh were used as substrates, in addition to a marked increase in the development of the chick embryo and chick.<BR>The ChE of liver reached its peak 15 to 18 days after the incubation of the fertilized egg. The activity of the ChE hydrolysed BuCh in liver was found higher than that of ChE hydrolysed ACh, McCh and BzCh. When ACh or MeCh were used as substrates, the ChE activity of the eye ball was high but not so in the case using BzCh.<BR>MAO activity in brain was found to increase during the incubation of the fertilized egg, and maximum activity was observed 3 days after hatching. An increase of MAO activity in liver and eye ball was found after hatching. These results suggest that most of the ChE activities in chicken were obtained during the embryo period. Inhibition of ChE activity by parathion (0.1 mg/egg) was found in liver alone. Organophosphate (Sumithion and Parathion) has no effect on the MAO activities in liver, brain and eye ball of either chick embryo or chick.
学校法人昭和大学・昭和医学会の論文