Prophylactic and Therapeutic Effect of Ketotifen Orally and by Aqueous Nasal Spray for Japanese Cedar Pollinosis.

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We studied the prophylactic and therapeutic effect of ketotifen in patients with Japanese cedar pollinosis.We administratered ketotifen orally to patients before the beginning of the dispersion of pollen.Ketotifen aqueous nasal spray (ketotifen-ANS) was administered to the poor-response groups in the prophylactic and therapeutic group.In the assessment of the final overall prophylactic effect 48.8% of the patients examined during the season showed "marked" or "moderate" effectiveness.The poor-response patients treated with ketotifen-ANS showed marked or moderate effectiveness in 83.2%. The therapeutic results were good in 59.3% of those treated after symptoms had started. Ketotifen-ANS was useful in both the poor-response and the therapeutic groups.The only side effect was sleepiness 7 patients receiving oral ketotifen. No abnormality was observed in those treated with ketotifen-ANS.Oral ketotifen and aqueous nasal spray ketotifen are considered to be excellent for the prophylaxis and therapy of Japanese cedar pollinosis.
耳鼻咽喉科臨床学会の論文