嗅神経芽細胞腫例

概要

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A 49-year-old female consulted our clinic with a complaint of righ trecurrent epistaxis on December 2, 1989. A tumor was found in the right nasal cavity. Radiographic study failed to disclose the extent of the tumor, because of associated paranasal sinusitis. MRI (magnetic resonance imaging) studies suggested that the tumor was limited to the right nasal cavity. Right lateral rhinotomy was performed and the tumor was totally removed on December 27, 1989. The tumor was confirmed to be neurogenic by the findings of intracytoplasmic neurosecretory granules and neuritic processes in the tumor cells examined by electron microscopy. It was diagnosed as olfactory neuroblastoma because of its location and the normal value of urine VMA (vanillyl mandelic acid). There was no evidencel of recurrence during 18 months of follow up. The authors confirmed the usefulness of MRI in the evaluation of the extent of the tumor and the necessity of electron microscopy to diagnose olfactory neuroblastoma.