タリビッドの扁桃・副鼻腔粘膜への移行

概要

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The distribution of ofloxacin (OFLX) in the tonsil and paranasal mucosa was quantitatively analyzed. OFLX was administrated 200 mg orally 3'1-4 hours before surgery. Then blood samples and tissue specimens were obtained simultaneously at operation. The OFLX tissue level proved to be related to the serum level. The tissue concentration of OFLX in the tonsil was 2.70 ±0.97ug/g and was higher than the serum concentration (1.90±0.57ug/ml). The tissue/ serum ratio was 1.44. On the other hand, the tissue concentration in the paranasal mucosa was 1.90±0.55ug/g. There was no significant statistical difference in OFLX concentration between paranasal mucosa and serum. The reason why penetration of OFLX to the tonsil exceeded that to the paranasal mucosa was discussed in the text. These tonsil and paranasal mucosa concentrations of OFLX were higher than the MIC50 of OFLX for bacteria that were found in common infections of both tonsil and paranasal mucosa. These kinetics of OFLX was not altered in elderly patient. These findings suggest that OFLX is a useful antibiotics which should be used for tonsillitis and sinusitis.
耳鼻咽喉科臨床学会の論文