Temporal bone histopathology in a patient with diffuse metastatic leptomeningeal carcinomatosis(DMLC).

概要

論文の詳細を見る
The histopathologic findings in the temporal bones of a 71-year-old male with bilateral deafness and facial paralysis due to DMLC originating from transitional cell carcinoma of the renal pelvis are described.The patient first noticed progressive bilateral hearing loss on July 17, 1986 (average loss rt. 35dB, it. 46dB) and became totally deaf bilaterally 4 weeks later. Several therapeutic measures had been tried without success to treat his bilateral sudden deafness of unknown cause. In September, he experienced left facial weakness, which progressed to complete paralysis bilaterally. Then he developed other cranial nerve paralyses (III, IV, IX, X) and meningeal symptoms. The CSF pressure was significantly increased as were the protein content and number of cells.The patient died on October 8, 1986 about 2 months after the onset of otologic symptoms.The temporal bones were removed 3 hours postmortem for histological study. The histopathologic findings in the two temporal bones were almost identical. The internal auditory meatus was filled with neoplastic tissue, which completely replaced the vestibulocochlear nerve bundles. The neoplastic cells infiltrated the modioli and Rosenthal canals of the cochleae diffusely through the cribrosa area, and some reached the scala tympani of the basal turns bilaterally. There was mild endolymphatic hydrops in the left cochlea and saccule, but the endolymphatic duct and sac appeared normal bilaterally. The facial nerve was completely destroyed by neoplastic cell invasion from the internal auditory meatus to the geniculate portion bilaterally. The external and middle ears were free of tumor.
耳鼻咽喉科臨床学会の論文

Temporal bone histopathology in a patient with diffuse metastatic leptomeningeal carcinomatosis(DMLC).

スポンサーリンク

概要

著者

関連論文

スポンサーリンク