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The effect of long-term administration (more than one year) of ATP with a dose of 300mg/day was examined in 20 patients with Meniere's disease.The rate of improvenent of more than a moderate degree was 100% for subjective symptoms such as vertigo and/or dizziness, hyperacousis and head heaviness, while objective symptoms including the results of auditory and equilibrium examinations improved at an effective rate of 25.0%. They were statistically superior compared to a short-term administration (4 weeks).When comparing the annual numbers of vertigo attacks before and after treatment, it was also confirmed that long-term administration of ATP markedly reduced the incidence of vertigo. Furthermore, despite its continued administration over one year, no appreciable side effects were observed, indicating its high safety.This kind of treatment seems to be and extremely useful measure for Meniere's desease which has the characteristic of repeated attacks over long term.
耳鼻咽喉科臨床学会の論文