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An intravenous infusion of 500ml of glycerol and normal saline was given over 90 minutes for the diagnosis and treatment of inner ear diseases such as Ménière's disease, sudden deafness, etc. Audiometry was performed before and one hour after the end of infusion. If the average hearing at 250, 500 and 1, 000Hz improved by more than 5dB, the glycerol infusion was considerd to be effective. Caloric nystagmus was evoked by 20ml of cold water for 20sec and recorded by electronystagmography with the eyes open in the dark. The mean values of the maximum slow phase velocity of caloric nystagmus before and after the infusion were compared.The hearing in 60 cases of Ménière's diseases showed improvement in 37% of the cases. In 21 cases of sudden deafness, the hearing improved in 52%. In all 8 cases of sudden deafness at the lower frequency (250, 500 and 1, 000Hz) the hearing improved. In 16 cases of sensorineural hearing loss, the hearing improved in 44%. The slow phase velocity of caloric nystagmus showed no improvement after the glycerol infusion.Thus, the intravenous infusion of 500ml of glycerol and normal saline can be used in the diagnosis and treatment of endolymphatic hydrops.
耳鼻咽喉科臨床学会の論文