Considerations on Treatment of Sudden Deafness

概要

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Improvement of blood supply to the inner ear is essential to recover hearing impairment produced by vascular disorder that is seemed to be possible cause of sudden deafness.Further we would like to stress two points: firstly, oxidative phosphorylation may be severely affected during interruption of blood supply. Secondly, both decrease in DPN-linked oxidations and leakage of intracellular potassium may occur as the results of decrease in ATP production.Our experiments have shown that ATP may prevent the morphological changes in mitochondria of the cochlear tissues during anoxia and activate the biochemically damaged tissues, in good agreement with the previous investigators.Therefore, we have presented the combined use of the measures for vascular dilatation (stellate ganglion block, microtinic acid injection), ATP injection and administration of both vitamine B complexes and vitamine B factors. This new therapeutic method seemed to be more effective to the cases of sudden deafness than the formers.Considering that the inner ear is sensitive to anoxia as well as the brain, the treatment of sudden deafness should be began as early as possible, after its onset. And large dosage of drugs should be administered to patient, since the inner ear is less permeable to drugs than the other organs are.
耳鼻咽喉科臨床学会の論文