The influence of exercise on the biomechanical and histological properties of the anterior cruciate ligament of bipedal rats.

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The purpose of this study was to investigate the influence of exercise on the anterior cruciate ligament of bipedal rats biomechanically and histologically.Thirty-six female Wistar rats were divided into three groups as follows: (1) Quadripedal rat [QG]; (2) Bipedal rat without exercise [B-E (-) G]; and (3) Bipedal rat with exercise [B-E (+) G].The rats of each group were terminated accordingly at the age of 20 weeks. The femur-anterior cruciate ligament-tibia prepared and arranged from each group were tested to failure on tensile testing machine and the anterior cruciate ligament of a group of rats were observed by light and electron microscopy.All femur-anterior cruciate ligament-tibia's complexes failed in the site of interstitial ligaments. The strength of the anterior cruciate ligament in B-E (+) G showed a significant increase as compared with QG and B-E (-) G. Observed under light microscopically there were no microtear and degradation change in the anterior cruciate ligament of each group, but again observed under electron microscopically the collagen fibril had a cross-sectional diameter of various sizes from 30nm to 110nm in the anterior cruciate ligament of B-E (+) G.
西日本整形・災害外科学会の論文