Effect of Granulocyte Colony Stimulating Factor(G-CSF) on Myelosuppression due to Chemotherapy for Malignant Bone and Soft Tissue Tumors.

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We studied 5 patients with grade 4 myelosuppresion after intensive chemotherapy in order to investigate the most effective time for administering G-CSF and to investigate the possibility of shortening the interval between chemotherapy treatments. We used G-CSF both before and immediately after the WBC count nadir. We found no merit in administering G-CSF before the WBC count nadir. Administration of G-CSF after the WBC count nadir was effective in promoting the recovery of neutrophils in all patients. Usual preventive methods against infection, such as washing, gargling and so on, must be stressed especially until the recovery of WBC counts. By administering G-CSF the interval between chemotherapy treatments could be shortened, and thereby more effect against malignant tumors could be expected.
西日本整形・災害外科学会の論文