カドミウム経口投与の魚に対する影響-4-コイおよびマダイにおける細胞学的所見

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Carp (Cyprinus carpio) of 258±37g were fed for 30 days (0, 140 and 1700ppm) or 14 days (5700ppm) on of feed containing, Cd of 0, 140, 1700 or 5700ppm in the dry weight Porgy (Pagrus major) of 73±7g. were fed for 113 days on feed containing Cd. of 0, 37.5, 150 or 375ppm in the dry weight. In the hepatic cells of both fishes fed on Cd-containing feed, the most remarkable altetions ware increase and enlargement of lysosomes with the increase of Cd content in feed. Decrease of glycogen granules (carp and porgy), increase and dilation of smooth-surfaced endoplasmic reticulum (carp), and increase of rough-surfaced endoplasmic reticulum (porgy) were noticed in the hepatic cells of Cdadministered fish. In the epithelial cells of the Proximal segment of renal tubule of both fishes fed on Cd-containing feed, the most remarkable alterations were increase and enlargement of lysosomes and apical vacuoles, increase of coated vesicles and apical tubules, and dilation of smoothsurfaced endoplasmic reticulum. These ultrastructural alterations in the liver and kidney are considered to be the effects of ingested Cd, and to imply functional disorders of both organs.
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