5-ヒドロキシトリプトファンによるシロザケ稚魚のトリプトファン欠乏性脊椎側彎症の発現阻止効果〔英文〕

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Tryptophan (Trp)-deficient diets (Trp 50mg/100g diet) supplemented with graded levels of 5-hydroxy-L-tryptophan (5-HTP; 0.1, 1, 10 & 100mg/100g diet) were fed to chum salmon fry Oncorhynchus keta to clarify whether 5-HTP, the precursor of serotonin (5-HT), prevents scoliosis caused by Trp deficiency and affects the levels of neurotransmitters in fish brain. The administration of the dose of less than 10mg of 5-HTP/100g diet caused scoliosis in 62-65% of fish atfer 4 weekrearing, whereas the increase in dietary level of 100mg reduced this value to 1.7%. 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) contents in the brain of the fish fed Trp-deficient diet containing 100mg 5-HTP/100g diet as well as those of Trp-sufficient diet (Trp 290mg/100g diet) were higher than those of the other dietary groups. The brain norepinephrine (NE) contents showed a tendency to rise as the supplemental level of 5-HTP increased. These results clearly indicate that the oral administration of 5-HTP up to the level of 100mg/100g dict or 40mg/kg body weight/day can almost completely prevent occurrence of scoliosis. Incidence of scoliosis in the fish fed Trp-free diet (Trp 0%) was only 15% even though brain 5-HT content of this group was in the same range as those fed Trp-deficient diet containing supplemental 5-HTP up to 10mg/100g diet. However, the brain NE and dopamine contents of the former were almost the same as those fed Trp-sufficient diet. These findings suggest that catecholamine may be also involved in an occurrence of scoliosis and that there is a considerable physiological difference between complete absence of Trp and intake of small quantity of Trp.
日本水産學會の論文

5-ヒドロキシトリプトファンによるシロザケ稚魚のトリプトファン欠乏性脊椎側彎症の発現阻止効果〔英文〕

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