体外免疫調節法に使われる材料

概要

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Extracoporeal immunomodulation is a newly developed medical technology which is defined as a therapeutic modality modulating immune system by extracorpreal treatment. 1. Plasma treatment 1.1. Simple plasma exchange : Since an end of the 1970s, membrane plasma separators which directly separate plasma from whole blood by filtration has fecome available. All cellular components are rejected while plasma components permeate through the membrane pores. Plasma containing immunologically pathogenic substances is discarded and replaced with healthy plasma. 1.2. Double filtration plasmapheresis (DFPP) : DFPP is a method which selectively separates macromolecular pathogenic plasma fraction by a differential filtration using a plasma separator and a plasma fractionator. 1.3. Immunoadsorption : Immune substances in plasma such as antigen, antibody or immune complexes are adsorbed either with biological adsorbing materials or synthetic materials. 2. Cell treatment 2.1. Lymphocyte removal : Malfunctioning lymphocytes are removed either from peripheral venous blood or thoracic duct lympha. Special filters which adsorb leucocytes, but not erythrocytes, are pressently avaiable. 2.2. Lymphocyte activated with interleukine II and returned to patients as a treatment of cancer.
日本膜学会の論文