細胞骨格系タンパクと細胞膜との相互作用

概要

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Interaction of cytoplasmic proteins with plasma membrane is one of the fundamental reaction in transmembrane control mechanism. With the advent of modern techniques in membrane biology and immunochemistry, the view on cytoskeletal system has been rapidly changed and now the system has been proved to involve many cellular functions such as cell movement, phagocytosis, secretion, mitosis, receptor redistribution and some membrane-linked physiological processes. The authors here reviewed the discoveries that have elucidated how the cytoskeletal system is linked to the plasma membrane and is organized in erythrocyte and nonmuscle cell. Furthermore, it is presented that the interaction is a function of physicochemical states of these proteins and lipids. Concerning with a disorganization of cytoskeletal structure in transformed cell, it is also introduced the phosphorylation of viculin a membrane associated actin-binding protein, by phosphoprotein 60src (pp 60src) in RSV-induced transformed cells. These results suggest that the cytoskeletal proteins have important roles in transmembrane signal in relation to the interaction with plasma membrane.
日本膜学会の論文