ラット肝ミトコンドリアに対する種々抗結核剤の影響(第1報)

概要

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From the viewpoint of host-drug relationship, studies were made about the effect of antituberculous drugs on oxidative phosphorylation and morphological change of mitochondria. As antituberculous drugs, INH, PAS, SM and KM etc. were employed. The mitochondria were isolated from the liver of adult m a l e rats according to the modified method of Hogeboom and Schneider. Using the apparatus specially devised by Utsumi, effects of antituberculous drugs on various factors, such as, respiratory control (R. C=, State 3/State 4), oxidative phosphorylation (ADP/0), oxidation-reduction of pyridine nucleotides and morphological structure of mitochondria were observed. Also ATP-Pi exchange reaction and ATPase activity were measured respectively by Hagiharas method and Takahashis method. The following results were obtained.
日本結核病学会の論文