Ethionamideによる脂肪肝の発現機序に関する実験的研究-5-Ethionamide投与ラットにおける肝および血清総コレステロール値の変動

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Some experiments were supplemented concerning the factors of fatty liver development induced by the oral administration of ethionamide (2-ethyl-thioisonicotinamide) to rats. 1) The liver total cholesterol level showed an increase of approximately 30% at 24 hours after the administration of ethionamide (200 or 400mg per kg body weight). 2) On the other hand, the serum total cholesterol level fell remarkably after the administration of ethionamide: it showed a decrease of 34.1% at 24 hours after the administration of 200mg ethionamide per kg body weight, and a decrease of 45.4% in the case of 400mg ethionamide per kg body weight. 3) There was a similar tendency both in the liver and serum total cholesterol levels of carbon tetrachloride-administered rats. 4) There was no obvious change in the serum GOT activity., whereas the serum GPT was twice as active as that of the control after the administration of ethionamide (400mg per kg body weight). 5) In carbon tetrachloride-administered rats, both GOT and GPT activities increased excessively. 6) From the results mentioned above and also of previous papers, it is suggested that the lipoprotein synthesis in liver or the release of lipids from liver to plasma ma y be impared because of the injuries of hepatic cells in ethionamide-administered rats, and therefore these factors may have some influence on fatty liver development together with other factors.
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