Ethionamideによる脂肪肝の発現機序に関する実験的研究-3-Ethionamide脂肝および副睾丸脂肪組織における脂肪酸組成の関連と血清遊離脂肪酸の変動

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As to the origin of the accumulated fat in liver of ethionamide (TH)-administered rat, an extrahepatic factor was investigated. 1. Comparing the e p ididymal adipose tissue of normal rat with that of TH-administered one in their fatty acid composition of total lipid, there was no remarkable difference in the proportion of each fatty acid to the total. 2. TH-induced fatty liver demon s trated an intermediate pattern between normal liver and normal epididymal adipose tissue in the fatty acid composition of total lipid. 3. The administration of TH resulted no remarkable change of serum free fatty acid content in rat 6 hours later, however, it caused an increase of nearly twofold to the control 12 hours later, which was recovered 24 hours later. 4. In carbon tetrachloride-administered rat, on the other hand, the content of serum free fatty acid showed a continuous increase from 6 hours after the administration and it reached more than twofold of that in the control rat 24 hours later. From these results, apart from any other factors, it is quite probable that in TH-administered rat as well as in carbon tetrachloride-administered one, the accumulated fat in liver was transported from the adipose tissue through circulatory flow.
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