ラット肝ミトコンドリアの呼吸系に及ぼすRifampicinおよびその誘導体の影響

概要

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Rifampicin possesses a high antibacterial activity both in vitro and in vivo against Mycobacterium tuberculosis and is used routinely as an effective antituberculous drug. In accordance with an increase in its application to pulmonary tuberculosis, however, various side effects caused by the administration of rifampicin have been reported. It has therefore become necessary to investigate the mechanism by which side effects occur. This paper describes some experiments planned to clarify the biological effects of rifampicin and its derivatives on liver mitochondria in connection with the relationship between liver functio n. disorders after the administration of rifampicin and the mitochondrial functions.
日本結核病学会の論文