各種の因子がRifampicinの結核菌最低発育阻止濃度に及ぼす影響に関する研究

概要

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Factors influencing the minimal inhibitory concentration (M.I.C.) of rifampicin for Myc. tuberculosis were examined. Used strains were H37Rv and a strain isolated from the sputa of a previously untreated pulmonary tuberculous patient. 1% Ogawa's egg media and Kirchner's semiliquid agar media with 10% albumin were used. Following results were obtained. 1) Influence of pH; on alkaline side, the M.I.C. was low with I% Ogawa's egg media and high with Kirchner's semi-liquid agar media. 2) On both media, the more the dose of inoculated bacilli, the higher the M.I.C. 3) The longer the inoculation period, the higher the M.I.C., on both media. 4) When the media are preserved in high temperature, the M.I.C. of rifampicin became higher in eary stage. The longer the preservation period, the higher the M.I.C. And the influence of the preservation temperature was more remarkable in I% Ogawa's egg media than in Kirchiner's semi-liquid agar media.
一般社団法人日本結核病学会の論文