Studies on the Experimental Typhoid:8g) Appearance and duration of cellular immunity of mouse immunized with live vaccine ofSalmonella enteritidis

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The mouse super-immunized with live vaccine of Salmonella enteritidis resisted intravenous injection of 1, 000 MLD of the same organism (Japan. J. Exp. Med., 30, 375-384). This anti-lethal resistance of mouse against the infection with S. enteritidis lasted for 16 months after the last injection of live vaccine (Japan. J. Exp. Med., 31, 187-190). The mononuclear phagocytes obtained from abdominal cavity, liver or subcutaneous tissue of mouse super-immunized with live vaccine did not allow the intracellular multiplication of bacteria regardless of the presence of antibody in the cell culture medium, whereas the cells obtained from normal mouse or the mouse immunized with dead vaccine did not (J. Bacteriol., 81, 863-868; J. Bacteriol., in press). This paper deals with the appearance and duration of cellular immunity of mouse when immunized with live vaccine of S. enteritidis. The mononuclear phagocytes were obtained from the abdominal cavity of mouse immunized with live vaccine of S. enteritidis and were maintained in cell culture for in vitro infection. It was found that the cells obtained from the mouse 3 weeks after immunization resisted the degeneration caused by intracellular multiplication of bacteria. Even after 13 months of the last injection of live vaccine the cells did not allow the intracellular multiplication of bacteria regardless of the presence of antibody in the cell culture medium.
日本細菌学会の論文