実験的チフス症の研究

概要

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The mice super-immunized with live vaccine of Salmonella enteritidis resisted intravenous injection with 1, 000 MLD of a virulent strain 116-54 of the same pathogen. The survivors of this challenge then completely resisted intravenous challenge with 10, 000 MLD of the same organism. The mononuclear phagocytes obtained from the abdominal cavity of mice immunized with live vaccine of S. enteritidis inhibited intracellular multiplication of virulent strain 116-54, regardless of the presence of antibody in the cell culture medium. The mononuclear phagocytes were obtained almost in pure state from liver or subcutaneous tissue of mouse and were maintained in vitro in good condition. And the cells obtained from the liver or subcutaneous tissue of mouse immunized with live vaccine of S. enteritidis also resisted the cellular degeneration caused by intracellular existence of virulent strain 116-54 regardless of the presence of antibody in the cell culture medium, whereas the cells obtained from normal mouse or the mouse immunized with dead vaccine did not.
日本細菌学会の論文